Mongevity: Longevity in Motion
Lipoprotein(a) barely changed after a heart attack, so one test stays reliable
In 199 patients with a major heart attack from the ASSAIL-MI trial, lipoprotein(a) rose only slightly in the first days, from a median of 17 to 25 nmol/L, and few patients changed risk category over six months.
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The immune system’s T cell variety drops faster after about age 50
An analysis of 1.32 billion T cell clones from 798 people with cancer and 5052 without, published in November 2026 in Aging Cell, found that T cell receptor diversity declines faster after…
A strong sweet tooth in the diet was linked to dementia risk and older-looking biology
A prospective cohort study published Oct. 7, 2026, in GeroScience found that people whose food preferences leaned strongly toward sweets had a 79% higher risk of dementia than those with health-aligned preferences,…
Stopping blood-thinning medicines in nursing home AFib was linked to higher mortality
A study of US nursing home residents with atrial fibrillation, published Oct. 1, 2026, in JAMA Network Open, found that stopping blood thinners on entry was not linked to more strokes or…
A pill raised progranulin, a protein missing in a genetic dementia, in a first human trial
In a first-in-human trial in 79 healthy adults, the oral drug VES001 was well tolerated and raised levels of progranulin, a protein that is too low in one genetic form of frontotemporal…
Social isolation and loneliness leave different marks on the brain, a review finds
A systematic review of 42 studies, published in October 2026 in Alzheimer's & Dementia, found that social isolation and loneliness are linked to partly different brain regions, and both to more white…
An anti-inflammatory ALS drug showed no benefit and raised liver enzymes
In the HIMALAYA trial of 305 people with ALS in 13 countries, the RIPK1 inhibitor SAR443820 did not slow functional decline over 24 weeks and caused more liver enzyme increases than placebo.
More people with rectal cancer are skipping surgery to ‘watch and wait’
A US study published Oct. 1, 2026, in JAMA Network Open found that 'watch and wait', skipping surgery after a strong response to treatment, rose from 2.30% of rectal cancer patients in…
Blocking a tumor ‘shield’ protein may boost immunotherapy before bladder surgery
In a small phase 2a trial published Oct. 24, 2026, in Nature Medicine, adding visugromab, which blocks the protein GDF-15, to nivolumab before bladder surgery led to no remaining cancer in 33%…
More ultra-processed food was linked to a higher risk of some blood cancers
In a UK Biobank study of 204,494 adults published Oct. 26, 2026, in the American Journal of Clinical Nutrition, each step up in the share of calories from ultra-processed food was linked…
In people with diabetes, high lipoprotein(a) was linked to a second heart attack
Pooling seven observational studies of 7887 people with type 2 diabetes after a heart attack or stent, high lipoprotein(a) was linked to about double the risk of another heart attack (hazard ratio…
Levodopa didn’t help movement recover after stroke, a Cochrane review finds
A Cochrane review published Oct. 29, 2026, pooled 12 randomized trials with 1860 people and found no evidence that levodopa or dopamine agonists improve motor function after stroke. Serious side effects were…
Placing the pacemaker wire in a different spot cut heart failure problems in a trial
In the LEAP-Block trial, published Oct. 28, 2026, in JAMA, people with heart block who got left bundle-branch area pacing had death, heart failure events or pacemaker upgrade in 2.4% of cases…
Not all whole grain is equal: intact grains lowered blood sugar a bit in type 2 diabetes
In a 12-week randomized trial of 160 adults with type 2 diabetes, people who ate intact whole grains ended with an HbA1c 2.2 mmol/mol lower than people who ate the same grains…